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How to Manage Constipation on GLP-1 Medications

Published 8 June 2026Evidence-based · 3 sources

Constipation is one of the most common side effects of GLP-1 medications — second only to nausea, especially in the first weeks and after a dose increase. The good news: a few simple eating and hydration habits make a big difference.

Why GLP-1 medications cause constipation

GLP-1 medications slow how quickly food moves through your stomach and gut. That's part of how they curb appetite — but the same slowing of intestinal transit is a common cause of constipation. A smaller appetite often means you're also eating less fibre and drinking less, which compounds the problem.

Get enough fibre — the right way

Drink more than you think

GLP-1 medications blunt thirst as well as hunger, so mild dehydration sneaks up — and adequate fluid is central to managing these GI side effects. Sip water steadily through the day rather than relying on feeling thirsty.

Keep moving

Gentle, regular movement — even a daily walk — helps keep your digestion moving. It's a simple, no-downside habit that supports everything above.

Supplements: check first

Some people use a psyllium fibre supplement or magnesium to stay regular. These can help, but they should fit your overall plan — check with your doctor or pharmacist first, especially alongside other medications. We don't provide dosing advice.

When to see a doctor

Contact your healthcare provider if constipation is severe, lasts more than a few days, or comes with significant pain, bloating, or vomiting. They can adjust your dose or rule out other causes.

This is general nutrition information, not medical advice. For persistent or severe symptoms, or before starting any supplement, talk to your doctor or dietitian.

Frequently asked questions

Why do GLP-1 medications cause constipation?
GLP-1 medications slow how quickly food moves through your stomach and gut — the same effect that reduces appetite also slows intestinal transit, which commonly leads to constipation. Eating less fibre and drinking less (because thirst is also blunted) make it worse.
How much fibre should I aim for?
A common target is about 25 g of fibre a day for women and up to roughly 38 g for men, from a mix of soluble (oats, beans, lentils, psyllium) and insoluble (whole grains, vegetables) sources. Increase fibre gradually and with plenty of fluid — adding fibre without water can make constipation worse.
When should I see a doctor about constipation?
Contact your healthcare provider if constipation is severe, lasts more than a few days, or comes with significant pain, bloating, or vomiting. They can adjust your dose or rule out other causes. Always check before starting a fibre or magnesium supplement, especially alongside other medications.

References

  1. Nutritional priorities to support GLP-1 therapy for obesity (American Journal of Clinical Nutrition, 2025)
  2. Managing the gastrointestinal side effects of GLP-1 receptor agonists in obesity (Postgraduate Medicine, 2022)
  3. USDA — Dietary Guidelines for Americans 2020–2025